Tlc analysis of a drug component

Thin layer chromotography techniques was performed on a sheet of glass or aluminium foil which is coated with thin layer adsorbent material usually silica gel.

Tlc analysis of a drug component

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March 4, Subject: Thin-Layer Chromatographic Analysis of Drug Components Experiment 15 The purpose of this experiment is to determine the components of an unknown drug and identify it as one of six 6 commercial drugs by using thin-layer chromatography.

I added approximately a quarter of a tablet of acetaminophen, aspirin, caffeine, ibuprofen, salicylamide, and the unknown 19 to separate test tubes containing 2. I noticed that my unknown was a coated tablet.

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Tlc analysis of a drug component

Each solution was spotted along a labeled starting line on the silica gel TLC plate. The TLC plate was put into a developing chamber containing When the TLC plate finished developing, I observed the plate under UV light and noticed that the salicylamide was the only spot that fluoresced purple while all the other spots fluoresced blue and I also noticed that the unknown had 2 spots.

I traced around the spots for each solution on the TLC plate, the only spot that I did not see was the one for the ibuprofen. I then placed it into an iodine chamber and noticed that the acetaminophen turned a yellowish color. I measured that the solvent traveled 64mm up the TLC plate by using the starting line as a reference, and, by using that information, I was able to calculate the Rf value of each solution by using: Commercial DrugRf Value Acetaminophen0.

I can speculate that the other substance is the coating from the tablet of the unknown.If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

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Thin-Layer Chromatographic Analysis of Drug Component TLC is used because it is “sensitive, fast, simple and inexpensive analytical technique”2 (Mohrig ). The unknown solid (unknown #3 in this case) used in the experiment was obtained and added to a 2.

5ml of Ethanol/dichloromethane in a test tube. Abstract.

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Tlc analysis of a drug component
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